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MCE 国际站:Angiopoietin-1 Protein, Human (HEK293, Fc)
Angiopoietin-1 Protein, Human (HEK 293, Fc) 是一种带有 Fc 标签的重组血管生成素-1 蛋白。 Angiopoietin-1 蛋白是酪氨酸激酶的分泌配体,主要由血管内皮细胞和造血细胞表达。Angiopoietin-1 是治疗性血管生成和血管稳定的潜在生长因子。
Synonyms: rHuAngiopoietin-1/ANG1, Fc; AGP1; AGPT; Ang1; ANG-1; angiopoietin 1; Angiopoietin-1; ANGPT1
Species: Human
Source: HEK293
Biological Activity: Measured by the ability of the immobilized protein to support the adhesion of HUVEC human umbilical vein endothelial cells. The ED50 for this effect is 356.9 ng/ml, corresponding to a specific activity is 2801.905 units/mg.
研究背景:Angiopoietin-1is a secreted protein ligand for ‘tunica interna endothelial cell kinase. Angiopoietin-1 is primarily expressed in growing vascular ECs and a subset of hematopoietic cells. Ang 1 can induce distinctive vascularremodeling through highly organized angiogenesis and tightening of endothelial cell (EC) junctions.The structure of Ang1 consists a carboxyl-terminal fibrinogen-like domain that can binds to the Tie2 receptor (a central coiled-coil domain).Ang1 plays critical roles in vascular assembly, maturation and stabilization, coronary venogenesis and glomerular vascular protection during developmental and pathological angiogenesis.
蛋白编号:Q15389 (D256-F498)
基因 ID:284
产品分类:细胞因子和生长因子 | 血管生成素家族 | 血管生成素-1
Categories:Cytokines and Growth Factors | Angiopoietins | ANG-1
货号: HY-P70061
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