MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

BMP-4 Protein, Mouse (HEK293, Fc)

MCE 国际站：BMP-4 Protein, Mouse (HEK293, Fc)

骨形态发生蛋白 4 (BMP-4) 是一种多效性配体蛋白，属于 TGFβ 家族，参与血管系统循环，可以激活血管细胞上的受体。BMP-4 结合 I 型受体 (ALK-2/-3/-6) 和 II 型受体 (BMPR2, ACVR2A)，通过其促炎和促动脉粥样硬化作用增加斑块形成，促进氧化应激、内皮功能障碍和成骨分化。重组小鼠 BMP-4 蛋白 (HEK293, Fc) 全长 116 个氨基酸 (S293-R408)，由 HEK293 细胞表达，带有 N 端 rFc 标签。

Synonyms: BMP-2B; BMP-4; Bone morphogenetic protein 4; DVR4

Species: Mouse

Source: HEK293

研究背景：Bone Morphogenetic Protein 4 (BMP-4) is a ligand protein with pleiotropic, belongs to TGFβ family. BMP-4 involves in the vasculature circulation and can activate receptors on vascular cells.
BMP-4/TGFβ signaling can be terminated by inhibitory SMADs including SMAD6 and SMAD7, which are activated and induced by BMP signaling and switch off BMP signaling via multiple mechanisms.
BMP-4 is widely found in different animals, while the sequence in human is highly similar to Rat (96.81%), and mouse (97.54%).
BMP-4 is expressed by endothelial cells (ECs) in response to hypoxia and promotes vascular SMC proliferation. Therefore it inhibits the proliferation of smooth muscle cells (SMCs) isolated from the proximal pulmonary artery while induces proliferation of SMCs isolated from distal pulmonary arteries.
BMP-4 appears to be a marker and driver of vascular calcification, particularly in atherosclerosis.
BMP-4 induces angiogenesis, endothelial cells (ECs) proliferation, and migration.
BMP-4 is differentially expressed in calcified atherosclerotic plaques, serves as the linkers between atherosclerotic vascular calcification with mechanisms of normal bone formation.
BMP-4 increases plaque formation via their pro-inflammatory and pro-atherogenic effects, promoting oxidative stress, endothelial dysfunction and osteogenic differentiation.

蛋白编号：P21275 (S293-R408)

基因 ID：12159

产品分类：细胞因子和生长因子  |  转化生长因子-β 超家族  |  骨形态发生蛋白  |  骨形态发生蛋白 4

Categories：Cytokines and Growth Factors  |  TGF-beta Superfamily  |  Bone Morphogenetic Proteins (BMPs)  |  BMP-4

货号: HY-P74379

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。