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MCE 国际站:CNTF Protein, Mouse
CNTF 属于 IL-6 细胞因子家族,是一种多能性神经营养因子。CNTF 可保护视网膜锥细胞和视杆细胞的光感受器。CNTF 对多种中枢和外周神经系统神经元具有神经保护作用。重组小鼠 CNTF 蛋白,是由 E. coli 表达的 CNTF 重组蛋白 (A2-M198),不带标签。
Synonyms: rMuCNTF; Ciliary Neurotrophic Factor
Species: Mouse
Source: E. coli
Biological Activity: The ED50 is <30 ng/mL as measured by its ability to induce alkaline phosphatase production by TF-1 cells.
研究背景:Ciliary Neurotrophic Factor (CNTF) belongs to the IL-6 cytokine family. IL-6, IL-11 and CNTF are associated with cytokine trans signaling. CNTF shows a low affinity interaction with IL-6 receptor subunit alpha (IL-6Rα), leading to the formation and activation of the IL-6Rβ/gp130/LIFR signaling receptor complex. CNTF is also an extracellular signaling protein in the neuroretinal and the interphotoreceptor matrix, which is associated with the membranes of the RPE, Muller and photoreceptor cells. CNTF has neuroprotective effects on a variety of central and also peripheral nervous system neurons. Because it promotes differentiation and maturation of oligodendrocyte precursor cells to oligodendrocytes under in vitro conditions and thus improves remyelination. Importantly, it also increases the survival of mature oligodendrocytes. The similarity of human CNTF protein sequences to mice and rats was 81.82% and 84.0%, respectively.
蛋白编号:P51642 (A2-M198)
基因 ID:12803
产品分类:细胞因子和生长因子 | 神经营养因子 | 睫状神经营养因子
Categories:Cytokines and Growth Factors | Neurotrophic Factors | CNTF
货号: HY-P7147
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