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MCE 国际站:IGFBP-3 Protein, Human
IGFBP-3 Protein, Human属于胰岛素样生长因子结合蛋白家族,能够延长胰岛素样生长因子的半衰期,阻止胰岛素样生长因子与其细胞表面受体的相互作用,同时可以降低癌症的发生。
Synonyms: rHuIGF-BP3; IBP-3; IGF-binding protein 3; IGFBP-3
Species: Human
Source: E. coli
Biological Activity: The ED50 is <200 ng/mL as measured by serum free human MCF-7 cells, corresponding to a specific activity of >5.0 × 103 units/mg.
研究背景:Insulin-like Growth Factor-Binding Proteins (IGFBPs) modulate the actions of secreted insulin-like growth facts (IGFs) by binding to them and increase the IGF halflife in the extracellular milieu and circulation by sequestering them in this bound form. IGFBPs either enhance or inhibit IGF actions on target cells; the individual IGFBPs either inhibit or potentiate IGF effects on osteoblasts in bone. Insulin-like Growth Factor-Binding Protein 3 (IGFBP3) is involved in prolonging the half-life of the IGFs (from 12 minutes to 12 hours), inhibits interaction of IGFs with their cell surface receptors, as well as, it is a circulating reservoir of IGFs. Moreover, IGFBP3 functions in cancer reduction, by both IGF-dependent and IGF-independent mechanisms. IGFBP3 has been shown to reduce the risk of breast cancer in high doses. A high concentration of IGFBP3 prevents IGF1:IGF1R interaction and blocks the IGF1R tyrosine kinase activity, resulting in the inhibition of the formation of intracellular signaling cascades.
蛋白编号:P17936 (G28-K291)
基因 ID:3486
产品分类:细胞因子和生长因子 | IGF 家族 | 胰岛素样生长因子结合蛋白 3
Categories:Cytokines and Growth Factors | IGF family | IGFBP-3
货号: HY-P7020
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