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MCE 国际站:IGF-I/IGF-1 Protein, Human (70a.a)
IGF-I/IGF-1 Protein, Human (70a.a)是一种促进有丝分裂的细胞因子,与 IGF 受体结合,能够调节多种组织的生长,如神经组织、淋巴组织、生殖组织、平滑肌、内皮细胞和骨骼等,同时具有调节神经保护的作用。
Synonyms: rHuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I
Species: Human
Source: E. coli
Biological Activity: ED50 < 5 ng/mL, measured by a cell proliferation assay using FDC-P1 cells, corresponding to a specific activity of > 2.0 × 105 units/mg.
研究背景:Insulin-like growth factor (IGF) system has been shown to modulate growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone. Insulin-like Growth factor-1 (IGF-I) is produced by osteoblasts, and its mitogenic effects are mediated by their binding to the IGF plasma membrane receptors. The IGF type 1 receptor binding to both IGF-I and IGF-II, is thought to be the predominate receptor involved in mediating the effects of these growth factors in most cell types, including osteoblasts. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor capable of mediating neuroprotective and neuroplasticity mechanisms. Targeted overexpression of IGF-1 enhances the generation of hippocampal newborn neurons in brain-injured mice.
蛋白编号:P05019 (G49-A118)
基因 ID:3479
产品分类:细胞因子和生长因子 | IGF 家族 | 胰岛素样生长因子 1
Categories:Cytokines and Growth Factors | IGF family | Insulin-like Growth Factor I (IGF-1)
货号: HY-P7018
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