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MCE 国际站:TGF beta 1/TGFB1 Protein, Human (112a.a, HEK293)
TGF beta 1/TGFB1 蛋白最初被认为是一种诱导啮齿动物成纤维细胞生长的生长因子。TGF beta 1/TGFB1 蛋白可将细胞阻滞在 G1 期。TGF beta 1/TGFB1 是内源性调节细胞凋亡的因子。重组人 TGF beta 1/TGFB1 蛋白 是由 HEK293细胞表达的,A279-S390 片段的蛋白。
Synonyms: Transforming Growth Factor Beta-1; TGF-Beta-1; Latency-Associated Peptide; LAP; TGFB1; TGFB; TGF-β1; TGF beta1; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1
Species: Human
Source: HEK293
Biological Activity: Immobilized Human Mature TGF beta 1, No Tag at 0.5 μg/mL (100 μl/well) on the plate. Dose response curve for Human TGF-beta RII, mFc Tag with the EC50 of <8 ng/mL determined by ELISA.
研究背景:TGFβ is released from degranulating platelets and secreted by all of the major cell types participating in the repair process, including lymphocytes, macrophages, endothelial cells, smooth muscle cells, epithelial cells, and fibroblasts. Mammals express three isoforms of TGFβdesignated TGFβI, TGFβ2, and TGFβ3; TGFβ1 is the most abundant isoform in all tissues, and in human platelets it is the only isoform of the peptide. Certain cells such as retinal pigment epithelial cells secrete predominantly TGFβ2, and certain body fluids such as the aqueous and vitreous of the eye, amniotic fluid, saliva, and breast milk contain principally TGFβ2. TGFβ3 is the least studied of the TGFβ isoforms. It has been isolated from human umbilical cord and is secreted from certain cells, including myoblast celllines; however, it is usually less abundant than either TGFβ1 or TGFβ2 in both tissue and cell extracts. There are three fundamental directions of its activities: I. TGFβ1 regulates cell proliferation, growth, differentiation and cells movement. II. TGFβ1 has immunomodulatory effects. III. TGFβ1 has profibrogenic effects. TGFβ1 action can be local and systemic.
蛋白编号:P01137 (A279-S390)
基因 ID:7040
产品分类:细胞因子和生长因子 | 转化生长因子-β 超家族 | 转化生长因子β | 转化生长因子-β1 | 细胞因子和生长因子 | 神经营养因子 | 转化生长因子-β | 转化生长因子-β1
Categories:Cytokines and Growth Factors | TGF-beta Superfamily | Transforming Growth Factor-β | TGF-β1 | Cytokines and Growth Factors | Neurotrophic Factors | TGF- β | TGF-β1
货号: HY-P70543
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