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MCE 国际站:GM-CSF R alpha Protein, Human (HEK293, Fc)
GM-CSF R α 是集落刺激因子 2 异二聚体受体的 α 亚基。GM-CSF R α 以高特异性和低亲和力与细胞因子结合。GM-CSF R alpha 与 GM-CSF 结合并诱导细胞分化。GM-CSF R α 单克隆抗体可降低 GM-CSF 阳性细胞上的 GM-CSFRα 表达,并在类风湿性关节炎 (RA) 中表现出抗炎活性。GM-CSF R alpha Protein, Human (HEK293, Fc) 是一种由 HEK293 细胞表达的重组蛋白,其 C 末端带有一个 Fc 标签,由 320 (M1-G320) 个氨基酸组成。
Synonyms: Granulocyte-macrophage colony-stimulating factor receptor subunit alpha; GMR-alpha; CD116; CSF2RA; CSF2R; CSF2RY
Species: Human
Source: HEK293
Biological Activity: Measured by its ability to inhibit GM-CSF dependent proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is typically <15 μg/mL.
研究背景:GM-CSF R alpha is expressed on myeloid cells and on some non-hemopoietic cells, such as endothelial cells, not on T cells.
The amino acid sequence of human GM-CSF R alpha protein has low homology for mouse GM-CSF R alpha protein.
GM-CSF receptor (GM-CSFR) consists of two subunits, an α-subunit, which binds the cytokine with low affinity, and a larger β-subunit (beta common; βc), responsible for signaling, forming a ternary receptor complex. Signal transduction in response to the cytokines interleukin (IL)-3 and IL-5 is also mediated by βc; therefore, receptor specificity is due to GM-CSFRα. After binding GM-CSF to its receptor, Janus-kinase-2 (JAK-2) is recruited to the cytoplasmic domain of the β chain, and activation of JAK-2 occurs, which subsequently induces STAT-5 phosphorylation. This signaling pathway induces migration of STAT-5 dimers to the nucleus and promotes the transcription of various genes such as pim-1 and CIS to induce cell differentiation.
GM-CSFR α-subunit significantly increases positive synovial macrophages in the RA synovium. GM-CSFR α monoclonal antibody suppresses disease activity in the murine collagen-induced arthritis model.
蛋白编号:P15509 (M1-G320)
基因 ID:1438
产品分类:细胞因子和生长因子 | 集落刺激因子 | 粒细胞-巨噬细胞集落刺激因子受体 | GM-CSF R alpha | CD 抗原 | 巨噬细胞 CD 蛋白 | GM-CSF R alpha/CD116 | CD 抗原 | 单核细胞 CD 蛋白 | GM-CSF R alpha/CD116 | CD 抗原 | 内皮细胞 CD 蛋白 | GM-CSF R alpha/CD116
Categories:Cytokines and Growth Factors | CSF & Receptors | GM-CSFR | GM-CSF R alpha | CD Antigens | Macrophage CD Proteins | GM-CSF R alpha/CD116 | CD Antigens | Monocyte CD Proteins | GM-CSF R alpha/CD116 | CD Antigens | Endothelial cell CD Proteins | GM-CSF R alpha/CD116
货号: HY-P73083
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