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MCE 国际站:IL-12 Protein, Human (HEK293)
IL-12 Protein, Human (HEK293)是一种 HEK293 细胞来源的促炎细胞因子。
Synonyms: IL-12; Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40
Species: Human
Source: HEK293
Biological Activity: Measured in a cell proliferation assay using CTLL-2 cells. The ED50 for this effect is 0.2209 ng/mL, corresponding to a specific activity is 4.53×10^6 units/mg.
研究背景:Recombinant human IL-12 (hIL-12) is from the serum-free supernatants of stable IL-12-transduced HEK293 cells. Interleukin-12 is a heterodimeric, pro-inflammatory cytokine that is a key driver of cell-mediated immunity. Interleukin-12 (IL-12), previously known as natural killer cell stimulatory factor (NKSF) and cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric cytokine comprised of p40 and p35 subunits linked by an inter-subunit disulfide bridge. Among its many pleiotropic functions, IL-12 has been shown to induce: (i) IFNγ production; (ii) proliferation of activated T and NK cells; and (iii) TH1 differentiation. These functions are mediated by binding of intact IL-12 to its heterodimeric transmembrane receptor complex consisting of two chains, IL-12Rβ1 and IL-12Rβ2.
蛋白编号:P29459 (R23-S219) & P29460 (I23-S328)
基因 ID:3592&3593
产品分类:细胞因子和生长因子 | 白细胞介素 | 白细胞介素-12
Categories:Cytokines and Growth Factors | Interleukin & Receptors | IL-12
货号: HY-P7032
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