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CAS No. : 508-99-6
MCE 国际站:Hydrocortisone cypionate
产品活性:Hydrocortisone cypionate是一种合成的糖皮质激素和皮质类固醇酯。
研究领域:Immunology/Inflammation | Vitamin D Related/Nuclear Receptor
作用靶点:Glucocorticoid Receptor
In Vitro: Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells.
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