MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Q-VD-OPh

CAS No. : 1135695-98-5

MCE 国际站：Q-VD-OPh

产品活性：Q-VD-OPh 是一种不可逆的泛胱天蛋白酶 (caspase) 抑制剂，具有高效的抗凋亡能力。抑制胱天蛋白酶 7 的 IC₅₀ 值别为 48 nM，抑制胱天蛋白酶 1，3，8，9，10，12 的 IC₅₀ 值在 25-400 nM 之间。Q-VD-OPh 可抑制 HIV 感染。Q-VD-OPh 能透过血脑屏障。

研究领域：Apoptosis  |  Anti-infection

作用靶点：Caspase  |  HIV

In Vitro: Q-VD-OPh is a potent inhibitor of caspase-7 with an IC₅₀ of 48 nM utilizing a cell-free assay consisting of human recombinant caspase-7, Q-VD-OPh, and the substrate AMC-DEVD-pNa. Q-VD-OPh fully inhibits caspase-3 and -7 activity at 0.05 μM. Caspase-8 is also inhibited at low Q-VD-OPh concentrations. The cleavage of PARP-1 is fully prevented at 10 μM Q-VD-OPh. DNA fragmentation and disruption of the cell membrane functionality are both prevented at 2 μM Q-VD-OPh. Q-VD-OPh is significantly more effective in preventing apoptosis than the widely used inhibitors, ZVAD-fmk and Boc-D-fmk, and is also equally effective in preventing apoptosis mediated by the three major apoptotic pathways, caspase 9/3, caspase 8/10, and caspase12. Q-VD-OPh is not toxic to cells even at extremely high concentrations. QVD is also able to increase the expression of differentiation markers in acute myeloid leukemia (AmL) blasts. QVD alone or combined with VDDs increases differentiation and HPK1-cJun signaling in AmL cell context-dependent manner.

In Vivo: Chronic treatment with Q-VD-OPh prevents caspase-7 activation and limits the pathological changes associated with tau, including caspase cleavage. Q-VD-OPh could be a potential therapeutic compound for the treatment of Alzheimer's disease.

相关产品：Covalent Screening Library Plus  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Apoptosis Compound Library  |  Anti-Cancer Compound Library  |  Antiviral Compound Library  |  CNS-Penetrant Compound Library  |  Covalent Screening Library  |  Pyroptosis Compound Library  |  Anti-Alzheimer's Disease Compound Library  |  Anti-Blood Cancer Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Targeted Diversity Library  |  Heterocyclic Compound Library  |  Membrane Protein-targeted Compound Library  |  Mca-DEVDAP-K(Dnp)-OH  |  Peldesine dihydrochloride  |  Z-VAD-FMK  |  Abacavir sulfate  |  HIV-IN-6  |  Epicoccone B  |  Ditiocarb  |  OT-82  |  Phenoxodiol  |  AKN-028 acetate  |  Nevirapine  |  DAPTA  |  Aloperine  |  Elipovimab  |  HIV-1 inhibitor-52  |  PMEDAP  |  Integracin B  |  FNC-TP  |  DDX3-IN-1  |  Lobaplatin  |  Sennoside A  |  CK-666  |  HIV-1 inhibitor-44  |  Flavopiridol  |  Claficapavir  |  Atazanavir  |  1-Deoxymannojirimycin hydrochloride  |  TC14012  |  (Z)-9-Propenyladenine  |  Apabetalone

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-12305

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。