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Thiomyristoyl

CAS No. : 1429749-41-6

MCE 国际站：Thiomyristoyl

产品活性：Thiomyristoyl是高效特异性的SIRT2抑制剂，IC₅₀值为28 nM。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶点：Sirtuin

In Vitro: Thiomyristoyl (TM) is a potent SIRT2-specific inhibitor with broad anticancer activity but little effect on non-cancerous cells. SIRT2-inhibition promotes c-Myc ubiquitination and degradation, suggesting the therapeutic potential of TM to target certain c-Myc-driven cancers. TM could inhibit SIRT2 with an IC₅₀ of 28 nM, but inhibits SIRT1 with an IC₅₀ value of 98 μM and does not inhibit SIRT3 even at 200 μM. TM inhibits three human breast cancer cell lines, MCF-7, MDA-MB-468, and MDA-MB-231.

In Vivo: TM inhibits tumor growth in mouse models of breast cancer. TM does not cause significant toxicity in mice and no significant weight loss is observed in TM-treated mice. S5H, the acetyl-a-tubulin level is moderately but statistically significantly increased in tumors from TM-treated mice compared with those from vehicle-treated mice, suggesting that TM indeed inhibits SIRT2 in vivo.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Epigenetics Compound Library  |  Histone Modification Research Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Antioxidant Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Breast Cancer Compound Library  |  Targeted Diversity Library  |  Highly Selective Inhibitors Library  |  E1231  |  Cambinol  |  PROTAC Sirt2 Degrader-1  |  Resveratrol  |  SRT 1720 Hydrochloride  |  SIRT-IN-3  |  SRT 2104  |  Tenovin-6  |  Ganoderic acid D  |  Decapeptide-12  |  SIRT2-IN-11  |  AK-1  |  UBCS039  |  SIRT1-IN-2  |  CypD-IN-4  |  SIRT-IN-1  |  SIRT5 inhibitor 2  |  Sirt2-IN-1  |  SIRT1-IN-1  |  SRTCX1002  |  Nicotinamide riboside tartrate  |  Inauhzin  |  Nicotinamide-¹⁵N,¹³C₃  |  SRTCX1003  |  SIRT5 inhibitor 3  |  Sirtuin modulator 4  |  YK-3-237  |  SIRT5 inhibitor 4  |  SRT 1460  |  AC-93253

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