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CAS No. : 1956370-21-0
MCE 国际站:RIPA-56
产品活性:RIPA-56 是一种高效选择和代谢稳定的受体相互作用蛋白 1 (RIP1) 抑制剂,IC50 为 13 nM。RIPA-56 可用于研究全身炎症反应综合征。
研究领域:Apoptosis
作用靶点:RIP kinase
In Vitro: RIPA-56 shows efficient inhibition of RIP1 kinase activity, with an IC50 of 13 nM and no inhibition of RIP3 kinase activity at a 10 μM concentration. RIPA-56 also demonstrates potency in protection of murine L929 cells from TNFα/z-VAD-FMK (TZ)-induced necrosis (EC50=27 nM).
In Vivo: In the SIRS mice disease model, RIPA-56 efficiently reduces tumor necrosis factor alpha (TNFα)-induced mortality and multi-organ damage. Compared to known RIP1 inhibitors, RIPA-56 is potent in both human and murine cells, is much more stable in vivo, and is efficacious in animal model studies. RIPA-56 has an impressive PK profile in mice with a 3.1 h half-life, 22% oral bioavailability (P.O.), and 100% bioavailability from intraperitoneal injection (I.P.).
相关产品:Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | NF-κB Signaling Compound Library | Targeted Diversity Library | Protein-protein Interaction Inhibitor Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | RIPK1-IN-3 | RIP1 kinase inhibitor 1 | Desmethyl-WEHI-345 analog | RIP2 kinase inhibitor 2 | PROTAC RIPK degrader-6 | TP-030-1 | PK68 | RIPK1-IN-4 | MLKL-IN-4 | NecroIr2 | RIPK1-IN-14 | Oditrasertib | cRIPGBM chloride | KWCN-41 | GSK963 | AV123 | RIP2 Kinase Inhibitor 4 | Necrostatin 2 | RIPK1-IN-11 | RIP1 kinase inhibitor 5 | ICCB-19 hydrochloride | RIPK3-IN-2 | GSK2983559 active metabolite | OD36 | RIP2 kinase inhibitor 1 | GSK840 | RIPK1-IN-15 | Necroptosis-IN-1
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-101032
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