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RG14620

CAS No. : 136831-49-7

MCE 国际站：RG14620

产品活性：RG14620是 EGFR 抑制剂；IC₅₀ 值为3 μM。

研究领域：JAK/STAT Signaling  |  Protein Tyrosine Kinase/RTK

作用靶点：EGFR

In Vitro: RG14620 inhibits colony formation (IC₅₀=3 μM) and DNA synthesis (IC₅₀=1 μM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC₅₀=4 μM) and DNA synthesis (IC₅₀=1.25 μM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible.

In Vivo: RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals.

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