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MSDC 0160

CAS No. : 146062-49-9

MCE 国际站：MSDC 0160

产品活性：MSDC 0160 (Mitoglitazone) 是调节噻唑烷二酮的线粒体靶标 (mTOT) 的胰岛素增敏剂，也是线粒体丙酮酸载体 (MPC) 的调节剂。MSDC 0160 是一种噻唑烷二酮 (TZD)，具有抗糖尿病和神经保护活性作用。MSDC 0160 具有用于阿尔茨海默氏病的潜力。

研究领域：Protein Tyrosine Kinase/RTK  |  Metabolic Enzyme/Protease

作用靶点：Insulin Receptor  |  Mitochondrial Metabolism

In Vitro: MSDC 0160 (Mitoglitazone; 1-50 μM; for 24 hours) significantly decreases phosphorylation of mTOR at 20 and 50 μM.
?MSDC 0160 acts as insulin sensitizers without activating PPARγ.
?MSDC 0160 (10 μM; pretreatment 1 hour) prevents the MPP⁺ (10 μM)-induced loss of both tyrosine hydroxylase (TH)-immunoreactive differentiated Lund human mesencephalic (LUHMES) cells.
?MSDC 0160 (10 or 100 μM) prevents the loss of GFP-fluorescent dopaminergic neurons induced by MPP⁺ (0.75 mM) in nematodes.
?MSDC 0160 (10-20 μM) in conbination with IGF-1 prevents the loss of insulin content and maintains insulin secretion.
?MSDC 0160 (1-50 μM) treatment maintains human β-cell phenotype.

In Vivo: MSDC 0160 (Mitoglitazone; 30 mg/kg; oral gavage; daily; for 7 days) improves locomotor behavior, increases survival of nigral dopaminergic neurons, boosts striatal dopamine levels, and reduces neuroinflammation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice.

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