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Paprotrain

CAS No. : 57046-73-8

MCE 国际站：Paprotrain

产品活性：Paprotrain是可渗透细胞的kinesin MKLP-2 的抑制剂，抑制 MKLP-2 的 ATPase 活性，IC₅₀ 值为 1.35 μM，K_i 值为 3.36 μM，同时对 DYRK1A 有中等的抑制作用，IC₅₀值为 5.5 μM。

研究领域：Cell Cycle/DNA Damage  |  Cytoskeleton

作用靶点：Kinesin

In Vitro: Paprotrain has been screened on a panel of CNS kinases. While inactive (IC₅₀ >10 μM) on CDK5 and GSK3, it has shown a moderate activity on DYRK1A (IC₅₀=5.5 μM). Time-lapse microscopy shows that disrupting MKlp2 expression with paprotrain results in polar body extrusion failure. This could be rescued after rescuing oocytes from paprotrain in fresh medium. Cell cycle analysis shows that most oocytes are arrested at metaphase I or telophase I. However, oocyte spindle structure and chromosome alignment are not disrupted after the inhibition of MKlp2 by paprotrain. Paprotrain-treated porcine oocytes suffer failure of nuclear maturation. The number of oocytes arrested at early MI stage increase in a dose-dependent manner after KIF20A activity inhibition, while the percentage of oocytes that reach ATI and MII stages decrease after treatment.

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货号: HY-101298

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