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CAS No. : 1415379-56-4
MCE 国际站:T807
产品活性:T807是一种新型的tau正电子发射断层扫描 (PET) 示踪剂。
研究领域:Neuronal Signaling
作用靶点:Tau Protein
In Vitro: Aggregated tau protein is a major neuropathological substrate central to the pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD). In vitro autoradiography results show that [18F]T807 exhibits strong binding to PHF-tau positive human brain sections (Kd=14.6 nM). A comparison of autoradiography and double immunohistochemical staining of PHF-tau and Ab on adjacent sections demonstrates that [18F]T807 binding colocalizes with immunoreactive PHF-tau pathology, but does not highlight Ab plaques. [18F]T807 strongly binds to tau lesions primarily made of paired helical filaments in Alzheimer’s brains e.g. intra and extraneuronal tangles and dystrophic neurites. [18F]T807 off-target binding to neuromelanin- and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions is identified.
In Vivo: [18F]T807 is able to cross the blood–brain barrier and ished out quickly in mice model. [18F]T807 clears rapidly from the brain, with activity values decreasing from 4.43% ID/g at 5 minutes to 0.62% ID/g at 30 minutes. Kidney elimination is a significant clearance pathway, resulting in a maximum tracer concentration of 14.99% ID/g in the kidneys at 5 minutes, which decreases to 5.52% ID/g at 30 minutes. The accumulation of activity in muscle and bone remain relatively low throughout the PET scan.
相关产品:Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Neuronal Signaling Compound Library | FDA-Approved Drug Library | Antiviral Compound Library | CNS-Penetrant Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Alzheimer's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Human Metabolite Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | hAChE-IN-1 | Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 | IONIS-MAPTRx | hAChE-IN-2 | LY3372689 | Acetyl-PHF6 amide TFA | NQTrp | BSc3094 | Tau protein aggregation-IN-1 | Tau Peptide (275-305) (Repeat 2 domain) | Anandamide | Microtubule-associated protein tau (26-44) | Bepranemab | T808 | Sabeluzole | GSK-3 inhibitor 3 | hBChE-IN-1 | Acetyl-PHF5 amide | Tau protein (592-597), human TFA | BuChE-IN-5 | TTBK1-IN-1 | (-)Clausenamide | THK5351 | MG-2119 | GSK-3β inhibitor 13 | Gosuranemab | Semorinemab | 3'-DMTr-dG(iBu) | tau/Aβ40 aggregation-IN-1
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