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CAS No. : 1404091-23-1
MCE 国际站:NucPE1
产品活性:NucPE1 (Nuclear Peroxy Emerald 1) 是核定位荧光过氧化氢探针, 其特异性定位于细胞核,没有附加的靶向部分。
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
作用靶点:Reactive Oxygen Species
In Vitro: NucPE1 features two major visible region absorptions (λabs=468 nm, ε=27,300 M-1cm-1; λabs=490 nm, ε=26,000 M-1cm-1) and a weak emission (λem=530 nm, Φ=0.117). Reaction of NucPE1 with H2O2 triggers a fluorescence increase upon its conversion to fluorophore NucPE1, which possesses one major absorption band at 505 nm (ε=19,100 M-1cm-1) with enhanced emission (λem=530 nm, Φ=0.626). NucPE1 selectively accumulates in the nuclei of a variety of mammalian cell lines as well as in whole model organisms like C. clegans, where it can respond to subcellular changes in H2O2 fluxes.
In Vivo: NucPE1 maintains the ability to selectively target nuclei in vivo. NucPE1 imaging reveals a reduction in nuclear H2O2 levels in worms overexpressing sir-2.1 compared to wildtype congeners, supporting a link between this longevity-promoting sirtuin protein and enhanced regulation of nuclear ROS pools.
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货号: HY-101859
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