MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

FIIN-2

CAS No. : 1633044-56-0

MCE 国际站：FIIN-2

产品活性：FIIN-2 是 FGFR 的不可逆抑制剂，对FGFR1，FGFR2，FGFR3和FGFR4的IC₅₀ 值分别为3.1，4.3，27和45 nM。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：FGFR

In Vitro: FIIN-2 potently inhibits WT FGFRs (EC₅₀s in the 1- to 93-nM range) and the gatekeeper mutant of FGFR2 (EC₅₀ of 58 nM). FIIN-2 also moderately inhibits EGFR, with an IC₅₀ of 204 nM. FIIN-2 inhibits proliferation of FGFR1-4 Ba/F3 cells with EC₅₀s in the single- to double-digit nanomolar range and are especially potent against FGFR2, with EC₅₀s in the 1-nM range. FIIN-2 shows good potency against gatekeeper mutant V564F.

In Vivo: Treatment of fish in the embryonic state with either FIIN-2 causes defects to the posterior mesoderm similar to the phenotypes reported following genetic knockdown of FGFR or treatment with other reported FGFR inhibitors. FIIN-2 causes mild or severe phenotypes to the tail morphogenesis in all treated embryonic zebrafish.

相关产品：Covalent Screening Library Plus  |  Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Anti-Cancer Compound Library  |  Covalent Screening Library  |  Reprogramming Compound Library  |  Anti-Lung Cancer Compound Library  |  Angiogenesis-Related Compound Library  |  Targeted Diversity Library  |  Anti-Liver Cancer Compound Library   |  Anti-Prostate Cancer Compound Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Heterocyclic Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  FGFR4-IN-12  |  FGFR2-IN-2  |  Multi-kinase-IN-2  |  FGFR1 inhibitor-6  |  FGFR4-IN-4  |  FGFR3-IN-3  |  FGFR-IN-7  |  PP58  |  FGFR4-IN-10  |  Vosoritide acetate  |  ODM-203  |  ENMD-2076 Tartrate  |  R1530  |  Gunagratinib  |  Ponatinib hydrochloride  |  Nintedanib  |  Heparan Sulfate  |  CPL304110  |  Futibatinib  |  Trafermin  |  Roblitinib  |  PD173074  |  FGFR-IN-2  |  Lucitanib  |  Masitinib  |  Nintedanib-¹³C,d₃  |  Zoligratinib  |  BLU9931  |  MAX-40279 hemifumarate  |  Pazopanib-¹³C,d₃ hydrochloride

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-18602

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。