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KJ Pyr 9

CAS No. : 581073-80-5

MCE 国际站：KJ Pyr 9

产品活性：KJ Pyr 9 是 MYC 的抑制剂。体外实验中, KJ Pyr 9 抑制 MYC 的 K_d 值为 6.5±1.0 nM。

研究领域：Apoptosis  |  Autophagy

作用靶点：c-Myc  |  Autophagy

In Vitro: KJ Pyr 9 (KJ-Pyr-9) interferes with MYC-MAX complex formation in the cell in a protein fragment complementation assay.
KJ Pyr 9 specifically inhibits MYC-induced oncogenic transformation in cell culture and has no or only weak effects on the oncogenic activity of several unrelated oncoproteins.
KJ Pyr 9 preferentially interferes with the proliferation of MYC-overexpressing human and avian cells and specifically reduces the MYC-driven transcriptional signature.
KJ Pyr 9 against three cell lines (NCI-H460, MDA-MB-231, and SUM-159PT) is tested known to be dependent on increased MYC activity.
KJ Pyr 9 can inhibit the proliferation of all cell lines with IC₅₀ values between 5 and 10 μM.
KJ Pyr 9 is more sensitive (IC₅₀ values between 1 and 2.5 μM) for the proliferation of Burkitt lymphoma cell lines with constitutively high expression of c-MYC.

In Vivo: KJ Pyr 9 (i.p.; 10 mg/kg; daily; for 31 d) has the ability to halt tumor growth.

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