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BMS-3

CAS No. : 1338247-30-5

MCE 国际站：BMS-3

产品活性：BMS-3 是一种高效的 LIMK 抑制剂，抑制 LIMK1 和 LIMK2，IC₅₀ 分别为 5 nM 和 6 nM。

研究领域：Cell Cycle/DNA Damage

作用靶点：LIM Kinase (LIMK)

In Vitro: BMS-3 (Compound 2) causes a dose-dependent reduction in cell count and induces mitotic arrest by increases in total nuclear DNA intensity and histone H3 phosphorylation after 24 h treatment in A549 human lung cancer cells. BMS-3 inhibits A549 human lung cancer cells with EC₅₀ value of 154 nM. BMS-3 is used to demonstrate the direct participation of LIMK1 in the phosphorylation of Cofilin. Inhibition of p-LIMK with 1-50 μM of BMS-3 results in a dose-dependent decrease of p-Cofilin after 10 min incubation in capacitating conditions. As a control, sperm are also incubated for 10 min under non-capacitating conditions which result in low levels of p-Cofilin. In the presence of 1 or 50 μM of BMS-3, actin polymerization levels are significantly lower compared to controls (DMSO). Mouse sperm are incubated under capacitating conditions for 90 min in the presence or absence of increasing concentrations of p-LIMK inhibitor BMS-3 (0, 1, 10 and 50 μM). The increasing concentrations of BMS-3 result in a strong decrease on the percentage of sperm that undergoes acrosomal exocytosis after stimulation with 20 μM of Progesterone.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Kinase Inhibitor Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Anti-Lung Cancer Compound Library  |  Targeted Diversity Library  |  TH-257  |  RSS0680  |  SR7826  |  T56-LIMKi  |  Aurora/LIM kinase-IN-1  |  Curcolonol  |  R-10015  |  SM1-71  |  DB1113  |  8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide  |  DD-03-156  |  CRT0105950  |  DB0614  |  LIMK1 inhibitor BMS-4  |  BMS-5  |  CRT 0105446  |  TH470

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