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CAS No. : 173529-10-7
MCE 国际站:HMN-176
产品活性:HMN-176 是二苯基乙烯的衍生物,能够抑制有丝分裂,干扰 plk1,但对微管蛋白的聚合影响不大。
研究领域:Cell Cycle/DNA Damage
作用靶点:Polo-like Kinase (PLK)
In Vitro: HMN-176 (2.5 μM) greatly increases the duration of mitosis in hTERT-RPE1 and CFPAC-1 Cell lines. The effect of HMN-176 on spindle morphology does not appear to be related to effects on microtubule polymerization. HMN-176 (2.5, 0.25, and 0.025 μM) inhibits aster formation in a concentration dependent manner. HMN-176 (0.1, 1.0, or 10.0 µg/mL) demonstrates inhibitory effects in multiple tumors, with notable activity seen in breast, nonsmall-cell lung, and ovarian cancer specimens. HMN-176 demonstrates activity towards 63% of the breast (5/8), 67% of the non-small cell lung (4/6), and 57% of the ovarian (4/7) tumor specimens treated with 10.0 µg/mL. HMN-176 shows potent cytotoxicity, with a mean IC50 value of 118 nM. HMN-176 displays similar cytotoxicity against tumors with various characteristics from different organs. Treatment with 3 μM HMN-176 suppresses the expression of MDR1 mRNA by 56%. HMN-176 has no significant effect on the residual promoter activity.
In Vivo: After p.o. of HMN-214 to male rats, the prodrug is not detected in the plasma, while plasma levels of HMN-176 peaks at 2 h and gradually decreases thereafter.
相关产品:Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Kinase Inhibitor Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Heterocyclic Compound Library | AAPK-25 | TAK-960 | Rigosertib sodium | PLK1/BRD4-IN-1 | Centrinone | Volasertib trihydrochloride | PLK1-IN-4 | Poloxin | Cyclapolin 9 | MLN0905 | SBE13 Hydrochloride | YLT-11 | (1E)-CFI-400437 dihydrochloride | Poloppin | CFI-400437 | ON1231320 | Wortmannin | Poloxime | CZS-241 | Plogosertib | Dihydrobaicalein
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-13647
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