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PFI-2 hydrochloride

CAS No. : 1627607-87-7

MCE 国际站：PFI-2 hydrochloride

产品活性：PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride 是一种强效的选择性 SETD7 抑制剂。(R)-PFI-2 具有高度抑制活性，其 IC₅₀ 值为 2.0??nM，(S)-PFI-2 的抑制活性 IC₅₀ 值为 1.0??μM。PFI-2 hydrochloride 可用于研究慢性肾脏疾病和肾纤维化发展过程中的炎症反应。

研究领域：Epigenetics

作用靶点：Histone Methyltransferase

In Vitro: (R)-PFI-2 shows high inhibiting activity with IC₅₀ value of 2.0 nM and (S)-PFI-2 shows inhibiting activity with IC₅₀ value of 1.0 μM.

In Vivo: PFI-2 hydrochloride (i.p., 200 μM, twice a week) attenuates the progression of renal fibrosis and preserves renal function in FA nephropathy.
PFI-2 hydrochloride (i.p., 200 μM, twice a week) reduced ECM accumulation and fibroblasts activation after FA injury.
PFI-2 hydrochloride (i.p., 200 μM, twice a week) impeded Th2 cytokine signaling activation and M2 macrophage polarization.
PFI-2 hydrochloride (i.p., 200 μM, twice a week) suppressed M2 macrophages-myofibroblasts transition and myeloid myofibroblasts accumulation in the FA-treated kidneys.
PFI-2 hydrochloride (i.p., 200 μM, twice a week) attenuated macrophages M2 polarization and M2 macrophages-to-myofibroblasts transition in obstructed kidneys.
PFI-2 hydrochloride (i.p., 200 μM, twice a week) suppressed myeloid myofibroblast accumulation and renal fibrosis after UUO injury.
PFI-2 hydrochloride (i.p., 200 μM, twice a week) reduced the infiltration of inflammatory cells, the production of inflammatory molecules, and NF-κB activation in FA nephropathy.

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