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CAS No. : 359600-10-5
MCE 国际站:RNPA1000
产品活性:RNPA1000 是一种抗生素,一种有效的 RnpA 抑制剂,可以抑制 RnpA 介导的细胞 RNA 降解。RNPA1000 抑制 tRNA 成熟,IC50 为 175 μM。RNPA1000 具有广谱抗菌活性,抑制葡萄球菌和所有革兰氏阳性细菌病原体。
研究领域:Anti-infection
作用靶点:Antibiotic | Bacterial
In Vitro: RNPA1000 displays antimicrobial activity toward Gram-positive bacteria and little or no toxicity toward human cells.
RNPA1000 limits S. aureus mRNA turnover and growth. RNPA1000 also limits growth of other important Gram-positive bacterial pathogens, exhibits antimicrobial efficacy against biofilm associated S. aureus and protects against the S. aureus pathogenesis in an animal model of infection.
RNPA1000 (IC50= 100-125 µM), does not affect the activity of the commercially available E. coli RNase HI, RNase A, RNase I or in-house purified S. aureus RNase J1 at any concentration tested (0-750 µM), but does mildly inhibit E. coli RNase III activity (IC50= 500-750 µM).
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热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-12824
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