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CAS No. : 443104-02-7
MCE 国际站:CDDO-Im
产品活性:CDDO-Im (RTA-403) 是 Nrf2 和 PPAR 的活化剂,对 PPARα 和 PPARγ 的 Ki 分别为232 nM 和 344 nM。
研究领域:NF-κB | Vitamin D Related/Nuclear Receptor | Cell Cycle/DNA Damage | Apoptosis
作用靶点:Keap1-Nrf2 | PPAR | Ferroptosis
In Vitro: CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines (IC50 approximately 10-30 nM). In U937 leukemia cells, CDDO-Im also induces monocytic differentiation as measured by increased cell surface expression of CD11b and CD36. Treatment with CDDO-Im elevates protein levels of Nrf2, a transcription factor previously shown to bind ARE sequences, and increases expression of a number of antioxidant and detoxification genes regulated by Nrf2. CDDO-Im is one of the most potent synthetic triterpenoids shown to induce growth inhibition and apoptosis in various human cancer cells, including multiple myeloma, lung, pancreas and breast cancer. CDDO-Im treatment markedly induces cell cycle arrest at G2/M-phase and apoptosis in the triple-negative breast cancer cell lines, SUM159 and MDA-MB-231. The CD24−/EpCAM+ cells in SUM159 tumorspheres are significantly inhibited by CDDO-Im treatment. CDDO-Im also significantly decreases sphere forming efficiency and tumorsphere size in both primary and secondary sphere cultures.
In Vivo: CDDO-Im is a potent inhibitor of de novo inducible nitric oxide synthase expression in primary mouse macrophages. Moreover, CDDO-Im inhibits growth of B16 murine melanoma and L1210 murine leukemia cells in vivo. Injection of 10 nM (5.4 μg) of CDDO-Im almost completely blocks the ability of IFN-γ to induce iNOS, and treatment with as little as 1 nmol of CDDO-Im (0.54 μg) is partially effective.
相关产品:Covalent Screening Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Immunology/Inflammation Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Antioxidant Compound Library | Oxygen Sensing Compound Library | Ferroptosis Compound Library | Anti-Breast Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Lipid Metabolism Compound Library | Antidepressant Compound Library | Anti-Pulmonary Fibrosis Compound Library | Nuclear Receptor Compound Library | Osteogenesis Compound Library | Cancer Stem Cells Compound Library | Mitochondrial Protection Compound Library | Sorafenib-d4 | Lapatinib ditosylate | Mangiferin | Ciclopirox olamine | Curcumin | L-Glutamine-d5 | HDAC-IN-48 | LY518674 | Poricoic acid A | (S)-L-Cystine-15N2 | Bocidelpar | Retinoic acid | 5-Aminosalicylic Acid-d3 hydrochloride | Keap1-Nrf2-IN-1 TFA | L-Glutamine-13C5,15N2 | Naveglitazar | Lapatinib-d7 dihydrochloride | Sorafenib Tosylate | Deferiprone | Ertiprotafib | Cycloheximide | ATRA-biotin | Pravastatin sodium | YL-939 | (-)-Epicatechin | Resveratrol | Dopamine-d5 hydrochloride | 4-Hydroxyphenylacetic acid | Convallatoxin | MHY908
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-15725
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