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Diazoxide

CAS No. : 364-98-7

MCE 国际站：Diazoxide

产品活性：Diazoxide (Sch-6783) 是一种 ATP 敏感性的钾离子通道 (potassium channel) 激活剂，有潜力用于高胰岛素血症的研究。

研究领域：Membrane Transporter/Ion Channel  |  Autophagy

作用靶点：Potassium Channel  |  Autophagy

In Vitro: Diazoxide (Sch-6783) has a number of physiological effects, including lowering the blood pressure and rectifying hypoglycemia. Diazoxide has powerful protective properties against cardiac ischemia.
Diazoxide (Sch-6783) could protect NSC-34 neurons against the main sources of neurodegenerative damage. Diazoxide increases Nrf2 nuclear translocation in NSC-34 motoneurons and prevents endogenous oxidative damage.

In Vivo: Diazoxide (Sch-6783) attenuates postresuscitation brain injury, protects mitochondrial function, inhibits brain cell apoptosis, and activates the PKC pathway by opening mitoKATP channels.
Treatment with Diazoxide (Sch-6783) in wild-type mice decreases intraocular pressure (IOP) by 21.5±3.2% with an absolute IOP reduction of 3.9 ± 0.6 mm Hg.

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