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Morinidazole

CAS No. : 92478-27-8

MCE 国际站：Morinidazole

产品活性：Morinidazole 是一种口服有效的 5-硝基咪唑抗菌剂，在人体中通过 N⁺-葡萄糖醛酸化和磺化进行代谢。Morinidazole 可用于用于研究细菌感染，包括厌氧菌引起的阑尾炎、盆腔炎 (PID) 等。

研究领域：Anti-infection

作用靶点：Bacterial

In Vitro: Morinidazole can be metabolized to N⁺-glucuronide of S-morinidazole [M8-1] and N⁺-glucuronide of R-morinidazole [M8-2] via N⁺-glucuronidation, and sulfate conjugate of morinidazole [M7] via sulfation.
M7 is a substrate for organic anion transporter 1 (OAT1) and OAT3 (K_m=28.6 and 54.0 μM, respectively), M8-1 and M8-2 are the substrates for OAT3.
Morinidazole shows activity against Trichomonas vaginalis and Entamoeba histolytica in vitro, with MIC values of 2 μg/mL and 3 μg/mL, respectively.

In Vivo: Morinidazole (20 mg/kg or 25 mg/kg; p.o.; single dose) inhibits Trichomonas vaginalis and Entamoeba histolytica in vivo in rats with EC₅₀s of 20 mg/kg and 25 mg/kg, respectively.
Morinidazole (50 mg/kg; i.v.; 0.25, 0.75, 1.5 h) shows a different concentration in tissues after intravenous injection, with a higher concentration in liver, kidney, plasma than lung, heart, and spleen in mice.
Pharmacokinetic parameters of Morinidazole in control and 5/6 nephrectomized (Nx) rats

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