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CAS No. : 305834-79-1
MCE 国际站:SC79
产品活性:SC79,一个特异的、能透过血脑屏障的 Akt 激动剂,可激活胞质中 Akt,并抑制 Akt 膜转位。SC79 特异性结合Akt 的PH 结构域。
研究领域:PI3K/Akt/mTOR
作用靶点:Akt
In Vitro: SC79 augmentes Akt phosphorylation at both the Thr308 and S473 sites.
?SC79 (10.96 μM) induces cytosolic phosphorylation of Akt. SC79 enhances IGF1-induced Akt phosphorylation in both serum-starved cells and cells grown in serum-rich medium.
?SC79 reduces neuronal excitotoxicity and prevents stroke-induced neuronal death. SC79 suppresses PHAKTM-GFP plasma membrane translocation.
?SC79 restores proliferation of BRAT1 knockdown cells, and reduces the production of superoxide in mitochondria of MitoSox positive cells.
?SC79 upregulates FLIPL/S expression and consequently suppresses caspase-8 activation.
In Vivo: SC79 treatment, even at much high dose (0.4 mg/g of body weight), does not induce any detectable changes in body weight, survival rate, appearance, and behavior in mice.
?SC79 (10 mg/kg, i.p.) protects C57BL/6 mice from fas-induced fulminant hepatic failure.
?SC79 protects hepatocytes from TNFα-mediated apoptosis and mice from Gal/LPS-induced liver injury and damage.
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货号: HY-18749
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