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CAS No. : 1354825-58-3
MCE 国际站:WEHI-345
产品活性:WEHI-345 是一种有效的选择性 RIPK2 激酶 抑制剂,IC50 值为 0.13 μM。WEHI-345 在寡聚化结构域 (NOD) 刺激下可延迟 RIPK2 的泛素化和 NF-κB 的活化。
研究领域:Apoptosis
作用靶点:RIP kinase
In Vitro: WEHI-345 (500 nM; Raw 267.4 cells) is able to inhibit MDP-induced autophosphorylation activity of RIPK2 in cells.
WEHI-345 (500 nM; 0 hour, 2 hours, 4 hours, 8 hours; BMDMs or THP-1 cells) potently blocks MDP-induced transcription of the inflammatory mediators TNF and interleukin-6 (IL-6) in bone marrow-derived macrophages (BMDMs). In THP-1 cells, WEHI-345 reduces mRNA levels of NF-kB targets such as TNF, IL-8, IL-1b and A20.
In Vivo: WEHI-345 (20 mg/kg; intraperitoneal injection; twice daily; for 6 days; C57BL/6 male mice) treatment reduces disease score, inflammatory infiltrate, histological score and recruitment of dendritic cells to the site of inflammation. And improves body weight and reduces cytokine and chemokine levels, indicating an overall improvement of the condition in experimental autoimmune encephalomyelitis (EAE)-induced wild-type C57Bl/6 mice.
相关产品:Bioactive Compound Library Plus | Apoptosis Compound Library | Kinase Inhibitor Library | NF-κB Signaling Compound Library | Anti-Cancer Compound Library | Targeted Diversity Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | RIPA-56 | RIPK1-IN-3 | RIP1 kinase inhibitor 1 | Desmethyl-WEHI-345 analog | RIP2 kinase inhibitor 2 | PROTAC RIPK degrader-6 | TP-030-1 | PK68 | RIPK1-IN-4 | MLKL-IN-4 | NecroIr2 | RIPK1-IN-14 | Oditrasertib | cRIPGBM chloride | KWCN-41 | GSK963 | AV123 | RIP2 Kinase Inhibitor 4 | Necrostatin 2 | RIPK1-IN-11 | RIP1 kinase inhibitor 5 | ICCB-19 hydrochloride | RIPK3-IN-2 | GSK2983559 active metabolite | OD36 | RIP2 kinase inhibitor 1 | GSK840 | RIPK1-IN-15 | Necroptosis-IN-1
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