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CAS No. : 176199-48-7
MCE 国际站:Eglumegad
产品活性:Eglumegad (LY354740) 是一种有效,选择性的 group II (mGlu2/3) receptor 激动剂,对人mGlu2和mGlu3受体的 IC50 分别为5和24 nM。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:mGluR
In Vitro: Eglumegad (LY354740) down-regulates spots 1014, 1822 (hypoxia up-regulated protein 1), 4513 (an isoform of protein disulfide isomerase 3), 6204, 6312, 7306 (26S proteasome non-ATPase regulatory subunit 7) and protein spots 1013 and 6005 (destrin), and up-regulates spot 6507 (collapsin response mediator protein 1) in mouse cortical neurons.
In Vivo: Eglumegad (LY354740) (15 or 30 mg/kg, i.p.) has no effect on spatial working memory performance in Gria1 / or WT mice, and it has no effect on rewarded alternation testing with a short inter-trial interval in Gria1 / and WT mice at concentration of 30 mg/kg. Eglumegad (LY354740) (15 or 30 mg/kg, i.p.) reduces spontaneous locomotor activity in wild-type and Gria1 / mice. Eglumegad (LY354740) (15 mg/kg, i.p.) dreases novelty-induced hyperlocomotion in naive GluA1-KO and pre-handled GluA1-KO males, but not in females. Eglumegad (LY354740) (15 mg/kg, i.p.) significantly reduces the increased c-Fos expression of GluA1-KO males to the level of WT males, but not in of females. Eglumegad (LY354740) (10 mg/kg, i.p.) attenuates the immobilization stress-induced increase in BDNF mRNA expression in the rat mPFC.
相关产品:Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Neurotransmitter Receptor Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Activators Library | Decoglurant | VU6010572 | FPTQ | (S)-MCPG | L-Glutamine-d5 | Mavoglurant racemate | L-Glutamine-13C5,15N2 | DFMTI | VU0360172 | JNJ16259685 | FITM | VU0483605 | LSN2463359 | mGlu4 receptor agonist 1 | LSP4-2022 | AMN082 | JF-NP-26 | Xanthurenic acid-d4 | Talaglumetad hydrochloride | ABP688 | Fasoracetam | Kainic acid hydrate | VU 0364439 | mGluR2 antagonist 1 | 3,3'-Difluorobenzaldazine | trans-ACPD | VU 0357121 | PHCCC | DCG-IV | TCN238
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货号: HY-18941
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