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CAS No. : 97519-39-6
MCE 国际站:Ceftibuten
产品活性:Ceftibuten (Sch39720) 是一种具有口服活性的头孢菌素,在体外对多种革兰氏阴性和某些革兰氏阳性病原体具有较强的抗菌活性。
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
In Vitro: Ceftibuten (Sch39720) is highly active against Haemophilus influenza, Escherichia coli, Klebsiella sp., and Proteus sp. and moderately active against Serratia sp. and Streptococcus pyogenes. Ceftibuten is relatively inactive against enterococci and staphylococci and is only weakly active against Pseudomonas aeruginosa and obligate anaerobes. It is also stable in the presence of most β-lactamase-producing organisms except βBacteroides fragilis. Ceftibuten is very active against strains of the family Enterobacteriaceae (mean MIC for 90% of strains=0.25 μg/ml) but less active against Campylobacterjejuni (mean MIC for 90% of strains=16.0 μg/ml).
In Vivo: Ceftibuten, a biologically stableβ-lactam antibiotic, has been shown to be transported by the small peptide transport system, to have relatively high affinity for the carrier and to show clear stereoselective and proton-gradient dependent transport characteristics in rat intestinal brush-border membrane vesicles.
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