MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Exatecan

CAS No. : 171335-80-1

MCE 国际站：Exatecan

产品活性：Exatecan (DX-8951) 是一种 DNA 拓扑异构酶 I (topoisomerase I) 抑制剂，IC₅₀ 值为 2.2 μM (0.975 μg/mL)，可用于癌症研究。

研究领域：Cell Cycle/DNA Damage

作用靶点：Topoisomerase

In Vitro: Exatecan is a potent topoisomerase I inhibitor, with an IC₅₀ of 0.975 μg/mL. Exatecan Mesylate (DX-8951f) significantly inhibits the proliferation of several cancer cell lines, with mean GI₅₀s of 2.02 ng/mL, 2.92 ng/mL, 1.53 ng/mL, and 0.877 ng/mL for breast cancer cells, colon cancer cells, stomach cancer cells and lung cancer cells, respectively. Exatecan Mesylate (DX-8951f) displays cytotoxic activities against PC-6, PC-6/SN2-5 cells, with mean GI₅₀s of 0.186 and 0.395 ng/mL, respctively. Exatecan Mesylate (34 nM) stabilizes DNA-TopoI complexes in PC-6 and PC-6/SN2-5 cells.

In Vivo: Exatecan Mesylate (DX-8951f, 3.325-50 mg/kg, i.v.) exhibits antitumor activities in the mice model bearing tumor cells, without toxic death. Exatecan Mesylate (15, 25 mg/kg, i.v.) hightly inhibits MIA-PaCa, BxPC-3 primary tumor growth in the MIA-PaCa-2 early-stage model and early-stage model of BxPC-3. Exatecan Mesylate (15, 25 mg/kg, i.v.) also significantly suppresses BxPC-3 lymphatic metastasis and completely eliminates lung metastasis in the BxPC-3 late-stage cancer model.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Prostate Cancer Compound Library  |  Heterocyclic Compound Library  |  Highly Selective Inhibitors Library  |  Gepotidacin  |  Topoisomerase IV inhibitor 2  |  Phenoxodiol  |  Topotecan hydrochloride hydrate  |  NHC-triphosphate tetraammonium  |  Berberine  |  Levofloxacin sodium  |  TAS-103 dihydrochloride  |  Ciprofloxacin  |  Mitoxantrone diacetate  |  Murrayanol  |  Gimatecan  |  Camptothecin  |  EGFR-IN-57  |  SW044248  |  Topoisomerase I/II inhibitor 4  |  NHC-diphosphate triammonium  |  Betulinic acid  |  ICRF-196  |  3,6-Diamino-9(10H)-acridone  |  Epirubicin  |  12-Ethyl-9-hydroxycamptothecin  |  Topoisomerase II inhibitor 3  |  Becatecarin  |  Pixantrone hydrochloride  |  Datopotamab deruxtecan  |  Isosteviol

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-13631

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。