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CAS No. : 42017-89-0
MCE 国际站:Fenofibric acid
产品活性:Fenofibric acid 是 fenofibrate 的活性代谢物,为 PPAR 激动剂,对 PPARα,PPARγ 和 PPARδ 的 EC50 值分别为 22.4 µM,1.47 µM 和 1.06 µM;Fenofibric acid 同时可抑制 COX-2 的活性,IC50 值为 48 nM。
研究领域:Cell Cycle/DNA Damage | Vitamin D Related/Nuclear Receptor | Immunology/Inflammation
作用靶点:PPAR | COX
In Vitro: Fenofibric acid is a PPAR activitor, with EC50s of 22.4 µM, 1.47 µM, and 1.06 µM for PPARα, PPARγ and PPARδ, respectively. Fenofibric acid (10, 25, 50, 75, and 100 nM) dose-dependently inhibits COX-2 enzyme, with IC50 of 48 nM. Fenofibric acid (500 nM) reduces abundance of AOX1 protein in HepG2 cells. Fenofibric acid (100 µM) decreases JNK1/2, c-Jun, and p38 MAPK phosphorylation, and prevents the accumulation of reactive oxygen species, endoplasmic reticulum (ER) stress and disruption of blood retinal barrier (BRB) in response to the combination of high-glucose (HG) and hypoxia in ARPE-19 cells. Fenofibric acid (100 µM) activates IGF-IR/Akt/ERK1/2-mediated survival signaling pathways in ARPE-19 cells under HG conditions and hypoxia.
In Vivo: Fenofibric acid (1, 5, 10 mg/kg, p.o.) shows anti-inflammatory activity in Wistar rats with acute inflammation induced by carrageenan.
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