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Sertindole

CAS No. : 106516-24-9

MCE 国际站：Sertindole

产品活性：Sertindole (Lu 23-174) 是一种具有口服活性的 5-HT_2A、5-HT_2C、dopamine D₂、和 αl-adrenergic 受体拮抗剂。Sertindole 表现出对多种癌症细胞的抗增殖活性并可用于抗精神病的研究。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Autophagy

作用靶点：5-HT Receptor  |  Dopamine Receptor  |  Adrenergic Receptor  |  Autophagy

In Vitro: Sertindole (0-100 μM; 48 h) attenuates proliferation of breast cancer cells.
Sertindole (0.8-27.6 μM; 48 h) inhibits proliferation toward many cancers in vitro.
Sertindole (5 μΜ and 10 μΜ; 24 h) attenuates migration of breast cancer cells.

In Vivo: Sertindole (oral gavage; 10 mg/kg; once daily; 12 d) shows anti-tumor activity in vivo.

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