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CAS No. : 313553-47-8
MCE 国际站:INH1
产品活性:INH1 通过直接结合 Hec1,特异性干扰 Hec1/Nek2 的相互作用。INH1 在体内和体外均表现出良好的抗肿瘤活性。
研究领域:Apoptosis
作用靶点:Apoptosis
In Vitro: INH1 (25 μM, 24 h) treatment resulted in reduced association of Hec1 with kinetochore and decrease of global Nek2 protein level.
INH1 exhibits GI50 values of 10.5 μM (in MDA-MB-468 cells), 15 μM (in SKBR3 cells), 10.5 μM (in T47D cells), 20.5 μM (in MDA-MB-361 cells), 15 μM (in ZR-75-1 cells), 15 μM (in HBL 100 cells), 15.5 μM (in MDA-MB-435 cells), 11 μM (in HS578T cells) and 41 μM (in MCF10A cells), respectively.
INH1 (5k) has an IC50 value of 176 nM in the dose-dependent transwell migration assays in MDA-MB-231 cells. INH1 (5k) substantially reduces cellular f-actin and prevented localization of fascin to actin-rich membrane protrusions.
INH1 induces abnormal mitotic processes, as well as cell apoptosis.
In Vivo: INH1 (50 or 100 mg/kg, i.p., every other day/25 cycles) inhibits tumor outgrowth in a xenografted breast cancer model in nude mice.
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