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CAS No. : 297730-17-7
MCE 国际站:AVN-944
产品活性:AVN-944 (VX-944) 是一种口服有效、选择性、非竞争性和特异性的 IMPDH (肌苷一磷酸脱氢酶)抑制剂。AVN-944 是从头合成鸟嘌呤核苷酸的必要限速酶。AVN-944 也是一种沙粒病毒 RNA 合成 (arenavirus RNA synthesis) 抑制剂,可阻断沙粒病毒感染。AVN-944 具有广泛的抗癌活性,可用于多发性骨髓瘤 (MM) 和急性髓系白血病 (AML) 的研究。
研究领域:Anti-infection | Cell Cycle/DNA Damage | Apoptosis
作用靶点:Arenavirus | DNA/RNA Synthesis | Apoptosis | Caspase | Bcl-2 Family
In Vitro: AVN-944 (0-1 μM, 48 h) inhibits growth of human multiple myeloma (MM) cell lines in a dose-dependent manner.
AVN-944 (800 nM, 0-72 h) induces apoptosis in MM cell lines via a caspase-independent, Bax/AIF/Endo G pathway.
AVN-944 (0-200 nM) enhances the cytotoxicity of Doxorubicin (HY-15142A) and Melphalan (HY-17575).
AVN-944 inhibits the proliferation of the human MV-4-11 and murine Ba/F3-Flt3-ITD-dependent cell lines with IC50 values of 26 and 30 nM, respectively.
AVN-944 (0-32 μM, 48 h) shows good activity against arenavirus infection at low doses (7.5 μM) with less cytotoxicity.
AVN-944 (0-6.4 μM, 48 h) does not reduce the viability of peripheral blood mononuclear cells (PBMNCs).
In Vivo: AVN-944 (0-150 mg/kg, Orally, twice daily) significantly increases the median survival time of leukemia model mice.
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货号: HY-13560
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