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CAS No. : 219766-25-3
MCE 国际站:ANA-12
产品活性:ANA-12是有效,选择性的 TrkB 拮抗剂,对高亲和力和低亲和力位点的IC50 分别为45.6 nM和41.1 μM。
研究领域:Neuronal Signaling | Protein Tyrosine Kinase/RTK
作用靶点:Trk Receptor
In Vitro: ANA-12 (10 nM) prevents BDNF-induced neurite outgrowth in the TrkB-expressing cells, and completely abolishes the effects of BDNF at concentrations up to 10-100 μM.
In Vivo: ANA-12 (0.5 mg/kg, i.p.) partially inhibits the total endogenous TrkB activity in the whole brain of mice. ANA-12, injected in mice, demonstrates anxiolytic and antidepressive activities at 0.5 mg/kg. ANA-12 (0.5, 1.0, and 2.0 mg/kg) does not affect neuron survival. ANA-12 (0.5 mg/kg) shows antidepressant effects in lipopolysaccharide (LPS)-induced depression-like behavior. ANA-12 (0.5 mg/kg) significantly attenuates an increased immobility time in depressed mice. In the TST, FST, and SPT, ANA-12 (0.5 mg/kg) does not show antidepressant-like effects in the control mice. ANA-12 (0.5 mg/kg, i.p.) reverses the diminished self-administration of cocaine in CocSired rats.
相关产品:Bioactive Compound Library Plus | Kinase Inhibitor Library | Neuronal Signaling Compound Library | Protein Tyrosine Kinase Compound Library | Human Metabolite Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | DS-1205b free base | LM22B-10 | TRK-IN-16 | PF-06733804 | Larotrectinib sulfate | Trk-IN-10 | AZ-23 | GNF-8625 monopyridin-N-piperazine hydrochloride | Trk-IN-7 | Protein kinase inhibitor 5 | TrkB-IN-1 | Bedinvetmab | TrkA-IN-1 | PF-6683324 | Cyclotraxin B | PF-06737007 | TRK-IN-21 | Sacibertinib | ENT-C225 | Entrectinib | Amitriptyline-d6 hydrochloride | Pan-Trk-IN-2 | Pan-Trk-IN-3 | Trk-IN-6 | Trk-IN-20 | GNF-5837 | TRK-IN-19
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货号: HY-12497
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