MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

(S)-(-)-Bay-K-8644

CAS No. : 98625-26-4

MCE 国际站：(S)-(-)-Bay-K-8644

产品活性：(S)-(-)-Bay-K-8644 是 L 型钙离子通道激动剂。(S)-(-)-Bay-K-8644 激活 Ba²⁺电流 (I_Ba)，EC₅₀ 为 32 nM。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：Calcium Channel

In Vitro: (±)-Bay K 8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca²⁺ channel agonist. Each optical isomer possesses opposite effects on IBa (R(+)-Bay K 8644 as an antagonist and (S)-(-)-Bay-K-8644 as an agonist. (S)-(-)-Bay-K-8644 can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on I_Ba in gastric myocytes of the guinea pig antrum. The Ca²⁺ channel activity is enhanced by 3–30 μM (S)-(-)-Bay-K-8644 an agonist of L-type Ca²⁺ channels. The interactions of two Ca²⁺ channel activators (S)-(-)-Bay-K-8644 and FPL 64176 is examined on smooth muscle L-type Ca²⁺ channels. FPL 64176 (300 nM) causes a sustained contraction of rat tail artery strips. This contractile response is inhibited by approximately 70% by (S)-(-)-Bay-K-8644 (EC₅₀=14 nM). (S)-(-)-Bay-K-8644 (100 nM) increases whole-cell Ca²⁺ currents in A7r5 smooth muscle cells but effectively blocks further stimulation by 1 μM FPL 64176.

相关产品：Bioactive Compound Library Plus  |  Membrane Transporter/Ion Channel Compound Library  |  Neuronal Signaling Compound Library  |  Reprogramming Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Benidipine hydrochloride  |  Isotachysterol 3  |  IAA65  |  Ranolazine-d₈ dihydrochloride  |  Diltiazem hydrochloride  |  Palmitoylglycine  |  Lercanidipine-¹³C,d₃-1 hydrochloride  |  Efonidipine hydrochloride monoethanolate  |  L-Ascorbic acid sodium salt  |  Taurolithocholic acid-d₄ sodium  |  Nilvadipine  |  N-type calcium channel blocker-1  |  Lercanidipine  |  SQ-31765  |  BMS-192364  |  CP-060  |  ISX-9  |  Nisoldipine-d₆  |  Catharanthine  |  Ginsenoside Rd  |  Manidipine dihydrochloride  |  Ziconotide  |  MMK1  |  Ranolazine-d₅  |  Isradipine  |  L-Ascorbic acid-¹³C₆  |  AE0047 Hydrochloride  |  Brompheniramine maleate

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-15124

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。