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CAS No. : 1125593-20-5
MCE 国际站:Mps1-IN-1
产品活性:Mps1-IN-1 是一种有效的,选择性的,ATP 竞争性的 Mps1 抑制剂,IC50 和 Kd 值分别为 367 nM 和 27 nM。
研究领域:Cell Cycle/DNA Damage | Cytoskeleton
作用靶点:Mps1
In Vitro: Mps1-IN-1 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC50 and a Kd of 367 nM and 27 nM. Mps1-IN-1 also has high affinity for ALK, and LTK, with Kds of 21 and 39 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-1 (5, 10 μM) induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells. Mps1-IN-1 disrupts recruitment of Mad2 to kinetochores, and reduces the phosphorylation status of Aurora B at threonine-232 (Thr232). Mps1-IN-1 (10 μM) shows no effect on centrosome duplication. In addition, Mps1-IN-1 (5-10 μM) suppresses the proliferative capacity of HCT116.
相关产品:Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Kinase Inhibitor Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Cytoskeleton Compound Library | Chemical Probe Library | Targeted Diversity Library | Highly Selective Inhibitors Library | TC-Mps1-12 | Mps1-IN-1 dihydrochloride | AZ3146 | Mps1-IN-3 hydrochloride | NMS-P715 | Mps1-IN-4 | BOS-172722 | RMS-07 | Mps-BAY2a | MPI-0479605 | Empesertib | BAY1217389 | CCT251455 | Mps1-IN-5 | Mps1-IN-2 | Mps1-IN-6
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货号: HY-13298
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