MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 2241337-84-6
MCE 国际站:Bemnifosbuvir hemisulfate
产品活性:Bemnifosbuvir hemisulfate (AT-527),AT-511 的半硫酸盐,是鸟苷核苷酸前体,是一种有效的具有口服活性的 HCV 病毒复制抑制剂。Bemnifosbuvir hemisulfate 有效抑制 SARS-CoV-2 (COVID-19) 感染 (EC90=0.47 μM)。Bemnifosbuvir hemisulfate 具有全基因型抗病毒活性。
研究领域:Anti-infection
作用靶点:HCV | SARS-CoV
In Vitro: Bemnifosbuvir hemisulfate has pan-genotypic antiviral activities that inhibits HCV genotype 1a (HCV GT1a), HCV GT1b, HCV GT2a, HCV GT3a, HCV GT4a, and HCV GT5a replication with EC50 values of 12.8 nM, 12.5 nM, 9.2 nM, 10.3 nM, 14.7 nM, and 28.5 nM, respectively.
In normal human airway epithelial cells, the concentration of Bemnifosbuvir hemisulfate required to inhibit replication of SARS-CoV-2 by EC90 is 0.47 μM, very similar to its EC90 against HCoV-229E, HCoV-OC43 and SARS-CoV in Huh-7 cells.
In Vivo: When given orally to rats (500 mg/kg) and monkeys (30 mg/kg, 100 mg/kg or 300 mg/kg), Bemnifosbuvir hemisulfate preferentially delivers high levels of AT-9010 in the liver in vivo.
相关产品:Covalent Screening Library Plus | Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Clinical Compound Library | Antiviral Compound Library | Drug Repurposing Compound Library | Covalent Screening Library | Orally Active Compound Library | Anti-Hepatitis C Virus Compound Library | Heterocyclic Compound Library | Sofosbuvir impurity J | Alisporivir | Antimicrobial agent-10 | SARS-CoV-2-IN-23 | PSI-7409 tetrasodium | 3CPLro-IN-1 | Dasabuvir | FNC-TP | DDX3-IN-1 | SP inhibitor 1 | rel-Zotatifin | Monodes(N-carboxymethyl)valine Daclatasvir | Antioxidant agent-9 | Regdanvimab | Silymarin | NHC-triphosphate tetraammonium | Sofosbuvir-d6 | Grazoprevir potassium salt | Atazanavir | Daclatasvir-d16 | FWM-4 | Amantadine-d6 | Deferiprone | Ketotifen fumarate | Dehydrojuncusol | Daclatasvir dihydrochloride | SARS-CoV-2-IN-27 | Ribavirin | MMT5-14 | Tipranavir
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-137958
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。