MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 439571-48-9
MCE 国际站:NDT 9513727
产品活性:NDT 9513727 是一种高效的,选择性的,具有口服活性的,竞争性的人类 C5aR 反向激动剂,其 IC50 值为 11.6 nM。NDT 9513727 可用于人类炎症疾病的研究。
研究领域:Immunology/Inflammation
作用靶点:Complement System
In Vitro: NDT 9513727 inhibits C5a-stimulated responses, including guanosine 5'-3-O-(thio)triphosphate binding, Ca2+ mobilization, oxidative burst, degranulation, cell surface CD11b expression and chemotaxis in various cell types with IC50s from 1.1 to 9.2 nM, respectively.
In Vivo: NDT 9513727 (3-30 mg/kg; p.o.) exhibits a dose-dependent inhibition of hC5a-induced neutropenia.
NDT 9513727 exhibits moderate oral bioavailability (rat 73%, monkey 26%) and Cmax (rat 5.98 μM, monkey 830 nM) following oral administration (rat 50, monkey 25.2 mg/kg).
NDT 9513727 exhibits moderate plasma elimination half-lives (rat 4.8, monkey 7.9 h) due to low plasma clearance (1.4 L/h/kg and 3.8 L/h/kg respectively) following oral administration (rat 50, monkey 25.2 mg/kg).
相关产品:Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Orally Active Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | FD-IN-1 | CP-447697 | Factor B-IN-2 | Ravulizumab | NRP1 antagonist 1 | ADH-503 | Avacincaptad pegol | NRP1 antagonist 2 | EG00229 | Dexamethasone-d4 | Complement C1s-IN-1 | Complement C5-IN-1 | Pozelimab | Phaseoloidin | Pexelizumab | Avdoralimab | POT-4 TFA | EG01377 | ARC186 | Certepetide | ATWLPPR Peptide TFA | Tesidolumab | Gefurulimab | Compstatin | Cyclosporin A | Cemdisiran, terminal sugar modification- | AMY-101 acetate | Factor D inhibitor 6 | BCX 1470
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-110060
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。