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CAS No. : 2751-09-9
MCE 国际站:Troleandomycin
产品活性:Troleandomycin (Triacetyloleandomycin) 是一种大环内酯类抗生素,是选择性的 CYP3A 抑制剂。Troleandomycin 是具有口服活性的、可用于哮喘研究的口服皮质类固醇。
研究领域:Metabolic Enzyme/Protease | Anti-infection
作用靶点:Cytochrome P450 | Bacterial
In Vitro: Troleandomycin markedly inhibits 6β-hydroxylation of testosterone, 25- and 26-hydroxylations of 5β-cholestane-3α,7α,12α-triol and 23R-, 24R-, 24S-, and 27-hydroxylations of 5β-cholestane-3α,7α,12α,25-tetrol in both recombinant CYP3A4 and microsomes, but IC50 values for microsomes are somewhat higher than those for recombinant CYP3A4.
In Vivo: Troleandomycin markedly suppresses these microsomal side chain hydroxylations in both mouse and human livers in a dose-dependent manner.
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