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CAS No. : 1256152-35-8
MCE 国际站:FIIN-1
产品活性:FIIN-1 是一种有效的,不可逆的选择性 FGFR 抑制剂。FIIN-1 与 FGFR1/2/3/4 和 Flt1/4 结合,Kd 分别为 2.8/6.9/5.4/120 nM 和 32/120 nM。FIIN-1 抑制 FGFR1/2/3/4 的 IC50 分别是 9.2,6.2,11.9 和 189 nM。
研究领域:Protein Tyrosine Kinase/RTK
作用靶点:FGFR
In Vitro: FIIN-1 binds to BLK, ERK5, KIT, MET, PDGFRB and VEGFR2 with Kds of 65 nM, 160, 420, 1000, 480 and 210 nM, respectively. The IC50s for Blk and Flt1 are 381 nM and 661 nM respectively.
FIIN-1 (14 nM-46 μM; 72 hours) inhibits proliferation of FGF signaling-sensitive cancer cell lines.
FIIN-1 (20 nM) inhibits iFGFR1 autophosphorylation and its downstream Erk1/2 almost completely.
相关产品:Covalent Screening Library Plus | Bioactive Compound Library Plus | Kinase Inhibitor Library | Protein Tyrosine Kinase Compound Library | Anti-Cancer Compound Library | Covalent Screening Library | Reprogramming Compound Library | Anti-Lung Cancer Compound Library | Angiogenesis-Related Compound Library | Anti-Liver Cancer Compound Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | FGFR4-IN-12 | FGFR2-IN-2 | Multi-kinase-IN-2 | FGFR1 inhibitor-6 | FGFR4-IN-4 | FGFR3-IN-3 | FGFR-IN-7 | PP58 | FGFR4-IN-10 | Vosoritide acetate | ODM-203 | ENMD-2076 Tartrate | R1530 | Gunagratinib | Ponatinib hydrochloride | Nintedanib | Heparan Sulfate | CPL304110 | Futibatinib | Trafermin | Roblitinib | PD173074 | FGFR-IN-2 | Lucitanib | Masitinib | Nintedanib-13C,d3 | Zoligratinib | BLU9931 | MAX-40279 hemifumarate | Pazopanib-13C,d3 hydrochloride
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货号: HY-15813
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