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Fenamic acid

CAS No. : 91-40-7

MCE 国际站：Fenamic acid

产品活性：Fenamic acid (N-Phenylanthranilic acid, NPAA) 是一种具有口服活性的氯通道阻滞剂。Fenamic acid 是非甾体抗炎剂 (NSAIA) 的基本成分，可衍生甲芬那酸 (mefenamic)，托芬那酸 (tofenacin)，氟芬那酸 (flufenamic acid) 和 美洛芬酸 (melofenac acid)。Fenamic acid 也可作为抗菌和镇痛剂。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Chloride Channel

In Vitro: Fenamic acid (N-Phenylanthranilic acid, NPAA) (2.5 mM; 3 h) inhibits Cl^- transportation and blocks ³⁶C1^- uptake and efflux in endothelial cells.
Fenamic acid exhibits selectivity to AKR1B10 (the tumor-marker) over human AR, and inhibits AKR1B10 with IC₅₀s of 0.76 μM (Flufenamic acid), 1.6 μM (Mefenamic acid), 9.89 μM (Meclofenamic acid), respectively.
Fenamic acid (4-16 µg/mL; 72 h) inhibits 50% of Neisseria gonorrhoeae with an MIC₅₀ value from 4 to 16 µg/mL (tolfenamic acid, flufenamic acid, and meclofenamic acid) in a low frequency of resistance.
Fenamic acid (2-8 µg/mL; 8 h) reduces the expression of the porinflammatory cytokines (IL-8, IL-6 and IL-ß) by infected endocervical cells without (>128 µg/mL; 24 h) inhibition towards commensal Lactobacillus spp. belonging healthy female genital microbiota.

In Vivo: RPA-1 is a biomarker in the detection of collecting duct injury in papillary necrosis in male rats.
Fenamic acid (N-Phenylanthranilic acid, NPAA) (350-700 mg/kg/day; o.p.; 4 d, 8 d, and 15 d) causes renal papillary necrosis and increases urinary renal papillary antigen-1 (RPA-1) in rats.
Fenamic acid (20 g/0.2 mL; i.p.) shows inhibitory effect against the abdominal constriction induced by acetic acid in mice.

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