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CAS No. : 2682114-54-9
MCE 国际站:SP-96
产品活性:SP-96 是一种高效、选择性和 ATP 竞争性 Aurora B 抑制剂,IC50 为 0.316 nM,对 FLT3 和 KIT 具有 >2000 倍选择性。SP-96 在 NCI60 筛选中表现出选择性生长抑制,对 MDA-MD-468 等乳腺癌细胞具有选择性 (GI50=107 nM)。SP-96 可用于三阴性乳腺癌 (TNBC) 的相关研究。
研究领域:Cell Cycle/DNA Damage | Epigenetics
作用靶点:Aurora Kinase
In Vitro: SP-96 is a highly potent, selective and non-ATP-competitive Aurora B (IC50=0.316 nM) inhibitor and shows >2000 fold selectivity against FLT3 (IC50=1475.6 nM) and KIT (IC50=1307.6 nM).SP-96 (0-1 µM; 24 hours) is not promiscuous, rather selective for a few cell lines, it inhibits MDA-MB-468, CCRF-CEM, COLO 205 and A498 cell growth with GI50 values of 107 nM,47.4 nM, 50.3 nM and 53.2 nM, respectively.SP-96 (63.2 nM) inhibits Aurora B activity in H460 cells by the characteristics of increased DNA content, and it increases cell volume with enormous nucleus.SP-96 (0-2 µM) inhibits Aurora B enzymatic activity with an IC50 of 0.316 nM and inhibits Aurora A with observed IC50 value of 18.975 nM. SP-96 shows >2000 fold selectivity against FLT3 (IC50=1475.6 nM) and KIT (IC50=1307.6 nM). Meanwhile, it exhibits inhibitory effects on other receptor tyrosine kinases (RTKs) namely EGFR, RET and HER2 with IC50 value ≥2 µM.
相关产品:Covalent Screening Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Cytoskeleton Compound Library | Anti-Breast Cancer Compound Library | Anti-Blood Cancer Compound Library | Targeted Diversity Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | AAPK-25 | AT9283 | Aurora kinase inhibitor-3 | Aurora Kinases-IN-2 | ENMD-2076 Tartrate | Barasertib-HQPA | dAURK-4 | AMG 900 | SCH-1473759 | Aurora A inhibitor 1 | BI-847325 | CCT129202 | Tripolin A | ZM-447439 | LY3295668 | TAK-632 | Aurora inhibitor 1 | MK-8745 | Ilorasertib | JB170 | PHA-680632 | Aurora kinase inhibitor-8 | SNS-314 | Hesperadin | Tozasertib | Alisertib | Aurora A/PKC-IN-1 | Derrone | KW-2449
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货号: HY-131339
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