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CAS No. : 3475-39-6
MCE 国际站:1,1,3-Tribromoacetone
产品活性:1,1,3-Tribromoacetone 是甲氨蝶呤 (HY-14519) 的杂质。Methotrexate (Amethopterin) 是一种抗代谢 (antimetabolite) 和抗叶酸剂 (antifolate),可抑制二氢叶酸还原酶,从而防止叶酸转化为四氢叶酸并抑制 DNA 合成。
研究领域:Metabolic Enzyme/Protease
作用靶点:Drug Metabolite
In Vivo: Methotrexate (Amethopterin) reduces thymus and spleen indices of mice. Methotrexate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice.Methotrexate (MTX) (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity.
相关产品:Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Anti-Cancer Compound Library | Drug Metabolite Library | Marine-Sourced Natural Product Library | Cysteine Targeted Covalent Library | Cysteine Targeted Covalent Fragment Library | Nicotinamide N-oxide | Cirsiliol 4′-glucoside | Desglymidodrine | 4-Methylamino antipyrine hydrochloride | Tazarotenic acid-d6 | Trospium EP impurity C-d8 chloride | Melamine | Febuxostat amide impurity | 20-Carboxy-Leukotriene B4 | O-Desmethyl Mebeverine acid-d6 | Desoxycarbadox | Ampyrone | Loxapine impurity 3-d8 iodide | HMMNI-d3 | N-Desmethyl imatinib mesylate | Cidofovir diphosphate tri(triethylamine) | 4-Hydroxymephenytoin-d3 | (Rac)-Nicotine EP impurity A-d4 hydrochloride | Tetrachlorocatechol | Ritalinic acid | 2-Aminoflubendazole-13C6 | AR-13324 M1 metabolite | 16α-Hydroxyprednisolone-d3 | Lurasidone metabolite 14326 hydrochloride | Ilaprazole sulfone | Metoprolol EP impurity O-d7 hydrochloride | N-Desmethyl Clomipramine-d3 hydrochloride | 1'-Hydroxymidazolam-13C3 | 1-β-D-Glucosylsphingadienine (d18:2 (4E8E))
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