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CAS No. : 29876-14-0
MCE 国际站:Nicotredole
产品活性:Nicotredole (Tryptamide) 是一种口服活性的消炎剂。Nicotredole 显示出与 Phenylbutazone 相当的明显抗炎作用。Nicotredole 仅具有弱的致溃疡活性。Nicotredole 可用于缓解疼痛的研究。
研究领域:Others
作用靶点:Others
In Vitro: Nicotredole inhibits prostaglandin synthetase activity in vitro.
In Vivo: Nicotredole produces antiinflammatory effects in carrageenin-induced rat paw oedema.
Nicotredole reverses pyrogen-induced hyperthermia in rats, elicits analgesic effects in rats, prolongs the time of hexobarbital sleep in rats and inhibits locomotor activity in rats and mice.
Nicotredole (i.p.) has LD50s of 1260 mg/kg and 1980 mg/kg for male rats and male mice, respectively.
Nicotredole (p.o.) has LD50s of 8.5 g/kg and 9.3 g/kg for male rats and male mice, respectively.
Nicotredole (25 mg/kg; p.o. or i.p.) undergoes fast absorption (t1/2=4.92-17.5 min) and elimination (t1/2=55.72-74.52 min), can reach Cmax (11-13 μg/cm3) after 30 min, and gives AUC values in the range of 21.40-27.30 (μg•h/cm3).
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