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21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione

CAS No. : 37413-91-5

MCE 国际站：21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione

产品活性：21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 是 delta 9,11 类固醇类合成的中间体 (intermediate)，如 Vamorolone (HY-109017)。delta 9,11 steroids 是糖皮质激素的修饰后的产物，具有抗炎 (anti-inflammatory) 特性。delta 9,11 类固醇类可以用作保护细胞损伤(脂质过氧化)和抑制新生血管的试剂。

研究领域：Immunology/Inflammation  |  Vitamin D Related/Nuclear Receptor  |  NF-κB

作用靶点：Glucocorticoid Receptor  |  NF-κB

In Vitro: Δ9,11 derivatives are designed and developed to stably incorporate into cell membranes and inhibit lipid peroxidation without glucocorticoid or mineralocorticoid activities, thus avoiding side effects associated with traditional corticosteroids.
VBP15 acts as a lead compound due to potent NF-κB inhibition and GR translocation similar to prednisone and dexamethasone, lack of transactivation properties, and good bioavailability.

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