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CAS No. : 13463-41-7
MCE 国际站:Zinc Pyrithione
产品活性:Zinc Pyrithione 能抗真菌和细菌,可通过阻断质子泵扰乱膜运输。Zinc Pyrithione 也是一种铜离子载体,可将铜输送到细胞中,是研究铜死亡 (cuproptosis) 的有用工具。
研究领域:Membrane Transporter/Ion Channel | Anti-infection
作用靶点:Proton Pump | Bacterial | Fungal
In Vitro: Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM.
Zinc Pyrithione (10 nM-10 μM; 72 hours) significantly induces cell death in AAVS1 cells.
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