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Homatropine Bromide

CAS No. : 51-56-9

MCE 国际站：Homatropine Bromide

产品活性：Homatropine Bromide 是一种具有口服活性的毒蕈碱受体 (muscarinic acetylcholine receptor) 拮抗剂，可用作抗胆碱剂。

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：mAChR

In Vitro: Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs, and produces a dose ratio of only 95.0 when combined with Hexamethonium Bromide (HY-B0569) in atrium from guinea-pigs.
Homatropine has affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses.

In Vivo: Homatropine methylbromide (9 mm x 5 mm conical suppository) causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure in rats.

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