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CAS No. : 68767-14-6
MCE 国际站:Loxoprofen
产品活性:Loxoprofen 是一种具有口服活性和解热作用的非甾体类抗炎药,可用于缓解疼痛的研究。Loxoprofen 是一种非选择性 COX 抑制剂,对 COX-1 和 COX-2 的 IC50 分别为 6.5 和 13.5 μM。Loxoprofen 可降低动脉粥样硬化,并具有抗肿瘤活性。
研究领域:Immunology/Inflammation
作用靶点:COX
In Vitro: Loxoprofen, an anti-inflammatory prodrug (NSAID), is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2 in human whole blood assays, respectively.
Loxoprofen (LOX) is a non-selective cyclooxygenase inhibitor that is widely used for the reasearch of pain and inflammation caused by chronic and transitory conditions. Its alcoholic metabolites are formed by carbonyl reductase (CR) and they consist of trans-LOX, which is active, and cis-LOX, which is inactive. In addition, LOX can also be converted into an inactive hydroxylated metabolite (OH-LOXs) by cytochrome P450 (CYP).
In Vivo: Loxoprofen sodium (4 mg/kg/day; p.o.; 1 or 8 weeks) reduces atherosclerosis in mice by reducing inflammation.Loxoprofen sodium (60 μg/mL; p.o.; 24 days) suppresses mouse tumor growth by inhibiting VEGF.
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